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Year : 2021  |  Volume : 4  |  Issue : 1  |  Page : 14-18

Occurrence and outcome of acute kidney injury in very low birth weight neonates

1 Department of Pediatric Nephrology, Government Medical College, Srinagar, Jammu and Kashmir, India
2 Department of Pediatrics, Government Medical College, Srinagar, Jammu and Kashmir, India

Correspondence Address:
Mohd Ashraf
Lecturer Pediatric Nephrology, Department of Pediatrics, Government Medical College, Srinagar, Jammu and Kashmir
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajpn.ajpn_33_20

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Background: Neonatal acute kidney injury (AKI) carries significant morbidity and mortality, particularly among very low birth weight (VLBW) neonates. We aimed to evaluate the short-term outcomes and the risk factors of AKI in VLBW infants. Methods: All extramural VLBW neonates without AKI and congenital renal abnormalities were enrolled. Serum creatinine (SCr) was estimated on days 0, 4, and 10. Neonatal AKI was defined an increase in SCr by ≥0.3 mg/dL from the previous value within a period of 48 h or >1.5 time from baseline within 7 days. Results: Neonatal AKI developed in 26 (13.8%) out of 189 neonates studied. Among AKI group, 5 (19.2%) had stage 1, 9 (34.4%) neonates reached stage 2, and 12 (46.1%) neonates reached stage 3 AKI. Neonates with AKI had a significantly lower gestational age and birth weight (P < 0.001). Mortality in VLBW neonates with AKI was significantly higher as compared to those without AKI (crude hazard ratio 6.2; 95% confidence interval: 2.36–15.79, P <0.05). Conclusions: AKI is common in extramural VLBW neonates, is inversely correlated with gestational age and birth weight, and carries poor outcome.

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